Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Molloy, F. M.
Right arrow Articles by Floeter, M. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Molloy, F. M.
Right arrow Articles by Floeter, M. K.
Related Collections
Right arrow Stiff person syndrome
Right arrow EMG

Neurology 2002;59:449-451
© 2002 American Academy of Neurology
Brief Communications

Increased brainstem excitability in stiff-person syndrome

F. M. Molloy, MD, M. C. Dalakas, MD and M. K. Floeter, MD, PhD

From the Electromyography Section (Drs. Molloy and Floeter) and Neuromuscular Diseases Section (Dr. Dalakas), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD.

Address correspondence and reprint requests to Dr. Mary Kay Floeter, NIH, NINDS, Building 10, Rm. 5C101, 10 Center Drive, MSC 1428, Bethesda, MD 20892-1428; e-mail: floeter{at}codon.nih.gov

The recovery cycle of the R2 component of the blink reflex was studied in five patients with stiff-person syndrome (SPS) and in seven healthy control subjects. R2 recovery was enhanced in patients with SPS. This result is suggestive of hyperexcitability of brainstem interneuronal circuits in SPS. Hyperexcitability may result from abnormal input from suprasegmental structures or loss of inhibition by interneurons and is compatible with the proposal that there is a widespread dysfunction of central inhibitory mechanisms in SPS.




This article has been cited by other articles:


Home page
 Arch NeurolHome page
L. M. Levy, I. Levy-Reis, M. Fujii, and M. C. Dalakas
Brain {gamma}-Aminobutyric Acid Changes in Stiff-Person Syndrome
Arch Neurol, June 1, 2005; 62(6): 970 - 974.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
C. Antozzi, C. Frassoni, A. Vincent, M. C. Regondi, F. Andreetta, P. Bernasconi, C. Ciano, T. Chang, F. Cornelio, R. Spreafico, et al.
Sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia
Neurology, April 12, 2005; 64(7): 1290 - 1293.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
S Khasani, K Becker, and H-M Meinck
Hyperekplexia and stiff-man syndrome: abnormal brainstem reflexes suggest a physiological relationship
J. Neurol. Neurosurg. Psychiatry, September 1, 2004; 75(9): 1265 - 1269.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by AAN Enterprises, Inc.