Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ward, H. J.T.
Right arrow Articles by van Duijn, C. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ward, H. J.T.
Right arrow Articles by van Duijn, C. M.
Related Collections
Right arrow Prion
Right arrow All epidemiology
Right arrow Case control studies
Right arrow Risk factors in epidemiology

Neurology 2002;59:543-548
© 2002 American Academy of Neurology

Sporadic Creutzfeldt–Jakob disease and surgery

A case–control study using community controls

H. J.T. Ward, MFPHM, D. Everington, MSc, E. A. Croes, MD, A. Alperovitch, MD, N. Delasnerie–Lauprêtre, MD, I. Zerr, MD, S. Poser, MD, C. M. van Duijn, PhD and for the European Union (EU) Collaborative Study Group of Creutzfeldt–Jakob Disease (CJD)*

From the National CJD Surveillance Unit (Dr. Ward and D. Everington), Western General Hospital, Edinburgh, UK; Department of Epidemiology and Biostatistics (Drs. van Duijn and Croes), Erasmus University Medical Centre Rotterdam, the Netherlands; U360 INSERM (Drs. Alperovitch and Delasnerie–Lauprêtre), Hôpital de la Salpetrière, Paris, France; and Neurologische Klinik (Drs. Zerr and Poser), Georg-August Universität, Göttingen, Germany.

Address correspondence and reprint requests to Dr. H.J.T. Ward, National CJD Surveillance Unit, Western General Hospital, Edinburgh, EH4 2XU, UK; e-mail: h.ward{at}ed.ac.uk

Background: The cause of sporadic Creutzfeldt–Jakob disease (CJD) is unknown. Previous studies found a link with a history of surgery but had methodologic problems.

Objective: To help elucidate medical and associated risk factors for sporadic CJD as part of the 1993 to 1995 European Union collaborative studies of CJD.

Methods: Medical and associated risk factors from 326 patients with sporadic CJD, taken from population-based studies performed between 1993 and 1995 in France, Germany, the Netherlands, and the UK, were compared with 326 community controls recruited by telephone in 2000.

Results: A history of surgery was significantly associated with the risk of sporadic CJD (odds ratio [OR]: 1.8; 95% CI: 1.2 to 2.6), which was not dependent on the number of surgical procedures, and was stronger in females (OR: 2.5; 95% CI: 1.5 to 4.0). Gynecologic (OR: 1.5; 95% CI: 1.0 to 2.3) and "other" operations (any operation other than neurologic, eye, ear, gallbladder, gastrointestinal, and gynecologic operations, tonsillectomy, and appendectomy) (OR: 1.5; 95% CI: 1.1 to 2.1) were associated with risk of CJD. Tonsillectomy (OR: 0.3; 95% CI: 0.2 to 0.5) and appendectomy (OR: 0.6; 95% CI: 0.4 to 0.8) were observed less frequently in cases. An increased risk was also found with a history of ear piercing in females (OR: 1.6; 95% CI: 1.1 to 2.5) and psychiatric visit(s) (OR: 2.6; 95% CI: 1.5 to 4.3).

Conclusions: These results support the hypothesis that cases of sporadic CJD may result from hitherto unrecognized surgical contamination events. However, because of the limits of the study design, the rarity of the disease, and the potential for bias, the results should be interpreted with caution.




This article has been cited by other articles:


Home page
 BrainHome page
G. M. Klug, H. Wand, A. Boyd, M. Law, S. Whyte, J. Kaldor, C. L. Masters, and S. Collins
Enhanced geographically restricted surveillance simulates sporadic Creutzfeldt-Jakob disease cluster
Brain, February 1, 2009; 132(2): 493 - 501.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
C A Heath, R A Barker, T F G Esmonde, P Harvey, R Roberts, P Trend, M W Head, C Smith, J E Bell, J W Ironside, et al.
Dura mater-associated Creutzfeldt-Jakob disease: experience from surveillance in the UK
J. Neurol. Neurosurg. Psychiatry, July 1, 2006; 77(7): 880 - 882.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. H. Peden, D. L. Ritchie, M. W. Head, and J. W. Ironside
Detection and Localization of PrPSc in the Skeletal Muscle of Patients with Variant, Iatrogenic, and Sporadic Forms of Creutzfeldt-Jakob Disease
Am. J. Pathol., March 1, 2006; 168(3): 927 - 935.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
B. Meissner, I. M. Westner, K. Kallenberg, A. Krasnianski, M. Bartl, D. Varges, C. Bosenberg, H. A. Kretzschmar, M. Knauth, W. J. Schulz-Schaeffer, et al.
Sporadic Creutzfeldt-Jakob disease: Clinical and diagnostic characteristics of the rare VV1 type
Neurology, November 22, 2005; 65(10): 1544 - 1550.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
L. Linsell, S. N. Cousens, P. G. Smith, R. S.G. Knight, M. Zeidler, G. Stewart, R. de Silva, T. F.G. Esmonde, H. J.T. Ward, and R. G. Will
A case-control study of sporadic Creutzfeldt-Jakob disease in the United Kingdom: Analysis of clustering
Neurology, December 14, 2004; 63(11): 2077 - 2083.
[Abstract] [Full Text] [PDF]

Home page
 Br J OphthalmolHome page
P S-Juan, H J T Ward, R De Silva, R S G Knight, and R G Will
Ophthalmic surgery and Creutzfeldt-Jakob disease
Br J Ophthalmol, April 1, 2004; 88(4): 446 - 449.
[Full Text] [PDF]

Home page
 NeurologyHome page
J. Mastrianni and R. P. Roos
"Out, damned spot! out, I say!. . .": Issues related to prion decontamination
Neurology, August 27, 2002; 59(4): 488 - 488.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by AAN Enterprises, Inc.