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Neurology 2002;59:560-562
© 2002 American Academy of Neurology

Transcranial magnetic stimulation for the treatment of seizures

A controlled study

W. H. Theodore, MD, K. Hunter, MD, R. Chen, MD, F. Vega–Bermudez, MD PhD, B. Boroojerdi, MD, P. Reeves–Tyer, BA, K. Werhahn, MD, K. R. Kelley, BA and L. Cohen, MD

From the Clinical Epilepsy (Drs. Theodore, Hunter, and Vega–Bermudez, and P. Reeves–Tyler and K. Kelley) and Human Cortical Physiology Sections (Drs. Chen, Boroojerdi, Werhahn, and Cohen), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD.

Address correspondence and reprint requests to William H. Theodore, MD, NIH, Bldg. 10, Rm. 5N-250, Bethesda, MD 20892; e-mail: theodorw{at}ninds.nih.gov

Objective: To perform a controlled trial of transcranial magnetic stimulation (TMS).

Methods: Twenty-four patients with localization-related epilepsy were randomized to blinded active or placebo stimulation. Weekly seizure frequency was compared for 8 weeks before and after 1 week of 1-Hz TMS for 15 minutes twice daily.

Results: When the 8-week baseline and post-stimulation periods were compared, active patients had a mean seizure frequency reduction of 0.045 ± 0.13 and sham-stimulated control subjects -0.004 ± 0.20. Over 2 weeks, actively treated patients had a mean reduction in weekly seizure frequency of 0.16 ± 0.18 and sham-stimulated control subjects 0.01 ± 0.24. Neither difference was significant.

Conclusion: The effect of TMS on seizure frequency was mild and short lived.




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