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Neurology 2002;59:633-636
© 2002 American Academy of Neurology
Brief Communications

Temporal lobectomy for epilepsy: Recovery of the contralateral hippocampus measured by 1H MRS

P. Vermathen, Dr rer nat, G. Ende, Dr rer nat, K. D. Laxer, MD, J. A. Walker, PhD, R. C. Knowlton, MD, N. M. Barbaro, MD, G. B. Matson, PhD and M. W. Weiner, MD

From the MR Unit, Department of Veterans Affairs Medical Center (Drs. Vermathen, Ende, Matson, and Weiner) and Departments of Neurology (Drs. Laxer, Walker, and Knowlton), Neurological Surgery (Drs. Laxer and Barbaro), Pharmaceutical Chemistry (Dr. Matson), Radiology (Dr. Weiner), and Medicine (Dr. Weiner), University of California, San Francisco.

Address correspondence and reprint requests to Michael W. Weiner, MD, Magnetic Resonance Unit, DVA Medical Center, 4150 Clement Street (114M), San Francisco, CA 94121; e-mail: mweiner{at}itsa.ucsf.edu

1H MRS imaging was obtained from 10 patients with mesial temporal lobe epilepsy before and after surgery. After surgery, metabolic recovery in the contralateral hippocampus was detected. Preoperatively, reduced N-acetylaspartate (p < 0.04) increased after surgery nonsignificantly to equal control values. Cholines increased after surgery (p < 0.02) and creatine–phosphocreatine showed a trend to higher values. The results suggest that the contralateral hippocampus is affected by repeated seizure activity in the ipsilateral hippocampus, rather than presence of bilateral mesial temporal sclerosis.




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