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From IRCCS S. Giovanni di Dio (Drs. Sandrini, Rossini, Sosta, and Miniussi), Brescia; Centro di Neuroscienze Cognitive (Dr. Cappa), Università Vita–Salute S. Raffaele, Milano; and Neurologia (Dr. Rossini), Università Campus Biomedico, Roma, Italy.
Address correspondence and reprint requests to Dr. Stefano F. Cappa, Centro di Neuroscienze Cognitive, Università Vita-Salute S. Raffaele, DIBIT Via Olgettina 58, 20132 Milano, Italy; e-mail: cappa.stefano{at}hsr.it
Background: Neuropsychological and neuroimaging studies suggest that whereas the left temporal neocortex plays a crucial role in all tasks involving lexical–semantic processing, some regions of the left prefrontal convexity are selectively recruited during verb processing.
Objective: To determine if there are different neural correlates for noun and verb processing in the human brain.
Methods: Repetitive transcranial magnetic stimulation (rTMS), 20 Hz at 90% of the motor threshold, was applied to left or right prefrontal brain during object- and action-naming tasks in nine healthy subjects.
Results: A shortening of naming latency for actions was observed only after stimulation of left prefrontal cortex.
Conclusion: The involvement of the left dorsolateral frontal cortex in action naming was demonstrated using rTMS.
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