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 Volume 59, Number 5, September 10, 2002
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Neurology 2002;59:744-746
© 2002 American Academy of Neurology
Brief Communications

Interferon ß1a and depression in secondary progressive MS: Data from the SPECTRIMS Trial

Scott B. Patten, MD, FRCP(C), PhD and Luanne M. Metz, MD, FRCP(C) for the SPECTRIMS Study Group*

From the Departments of Community Health Sciences and Psychiatry (Dr. Patten) and Clinical Neurosciences (Dr. Metz), University of Calgary, Alberta, Canada.

Address correspondence and reprint requests to Dr. S.B. Patten, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1; e-mail: patten{at}ucalgary.ca

Depression is a suspected side effect of treatment with interferon ß1a in MS. However, an association with depression has not been confirmed by rigorous studies. During the SPECTRIMS clinical trial of interferon ß1a (Rebif) in secondary progressive MS, depression ratings were obtained from 365 subjects treated either with interferon ß1a or with placebo. No significant differences between groups emerged during 36 months of follow-up. These data suggest that depression is not a side effect of interferon ß1a.


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