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From the Department of Epidemiology and Biostatistics (T. den Heijer, and Drs. van Duijn, Hofman, and Breteler), Erasmus Medical Center, Rotterdam; Department of Radiology (Dr. Oudkerk), Academic Hospital Groningen, the Netherlands; and National Institute on Aging (Dr. Launer), NIH, Bethesda, MD.
Address correspondence and reprint requests to Dr. M.M.B. Breteler, Department of Epidemiology & Biostatistics, Erasmus Medical Center, PO Box 1738, 3000 DR, Rotterdam, the Netherlands; e-mail: breteler{at}epib.fgg.eur.nl
The 
4 allele of the APOE gene increases the risk for AD, whereas the 2 allele may be protective. The authors assessed the impact of APOE genotype on hippocampal, amygdalar, and global brain atrophy as putative markers of preclinical AD in a nondemented population. Carriers of 4 had significantly more hippocampal and amygdalar atrophy than 33 subjects, but not more global brain atrophy. Carriers of 2 did not have less brain atrophy than 33 subjects.
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