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Neurology 2002;59:746-748
© 2002 American Academy of Neurology
Brief Communications

Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes

T. den Heijer, MSc, M. Oudkerk, MD, PhD, L. J. Launer, PhD, C. M. van Duijn, PhD, A. Hofman, MD, PhD and M. M.B. Breteler, MD, PhD

From the Department of Epidemiology and Biostatistics (T. den Heijer, and Drs. van Duijn, Hofman, and Breteler), Erasmus Medical Center, Rotterdam; Department of Radiology (Dr. Oudkerk), Academic Hospital Groningen, the Netherlands; and National Institute on Aging (Dr. Launer), NIH, Bethesda, MD.

Address correspondence and reprint requests to Dr. M.M.B. Breteler, Department of Epidemiology & Biostatistics, Erasmus Medical Center, PO Box 1738, 3000 DR, Rotterdam, the Netherlands; e-mail: breteler{at}epib.fgg.eur.nl

The {epsilon}4 allele of the APOE gene increases the risk for AD, whereas the {epsilon}2 allele may be protective. The authors assessed the impact of APOE genotype on hippocampal, amygdalar, and global brain atrophy as putative markers of preclinical AD in a nondemented population. Carriers of {epsilon}4 had significantly more hippocampal and amygdalar atrophy than {epsilon}3{epsilon}3 subjects, but not more global brain atrophy. Carriers of {epsilon}2 did not have less brain atrophy than {epsilon}3{epsilon}3 subjects.




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