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Neurology 2002;59:752-756
© 2002 American Academy of Neurology
Brief Communications

Diffusion tensor imaging of periventricular leukomalacia shows affected sensory cortex white matter pathways

A. H. Hoon, Jr., MD, MPH, W. T. Lawrie, Jr., AB, E. R. Melhem, MD, E. M. Reinhardt, MSN, P. C.M. van Zijl, PhD, M. Solaiyappan, BE, H. Jiang, PhD, M. V. Johnston, MD and S. Mori, PhD

From the Johns Hopkins University School of Medicine (Drs. Hoon, Melhem, van Zijl, Jiang, Johnston, and Mori, W. Lawrie and M. Solaiyappan), F.M. Kirby Research Center for Functional Brain Imaging (Drs. van Zijl, Jiang, and Mori), Kennedy Krieger Institute (Drs. Hoon, van Zijl, Jiang, Johnston, and Mori, and E. Reinhardt), and Johns Hopkins Hospital (Dr. Melhem), Baltimore, MD., Supported by NIH/NCRR resource grant P41 RR15241, HD37931 (R03); and the Charles A. Dana Foundation.

Address correspondence and reprint requests to Dr. Alexander H. Hoon Jr., Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205; e-mail: hoon{at}kennedykrieger.org

The authors used diffusion-tensor imaging to examine central white matter pathways in two children with spastic quadriplegic cerebral palsy. Corticospinal tracts projecting from cortex to brainstem resembled controls. In contrast, posterior regions of the corpus callosum, internal capsule, and corona radiata were markedly reduced, primarily in white matter fibers connected to sensory cortex. These findings suggest that the motor impairment in periventricular leukomalacia may, in part, reflect disruption of sensory connections outside classic pyramidal motor pathways.




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