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Neurology 2002;59:756-758
© 2002 American Academy of Neurology
Brief Communications

Genetic association of {alpha}2-macroglobulin polymorphisms with AD in southern Italy

M. Zappia, MD, R. Cittadella, PhD, I. Manna, PhD, G. Nicoletti, MD, V. Andreoli, PhD, S. Bonavita, MD, A. Gambardella, MD and A. Quattrone, MD

From the Institute of Neurology (Drs. Zappia, Gambardella, and Quattrone), University "Magna Græcia," Catanzaro; Institute of Neurology (Dr. Bonavita), 2nd University of Naples; and Institute of Neurological Sciences (Drs. Zappia, Cittadella, Manna, Nicoletti, Andreoli, Gambardella, and Quattrone), National Research Council, Piano Lago (Cosenza), Italy.

Address correspondence and reprint requests to Prof. Aldo Quattrone, Clinica Neurologica, Facoltà di Medicina, ViaT. Campanella, 88100 Catanzaro, Italy; e-mail: quattrone{at}neurol-unicz.it

The authors investigated the segregation of two polymorphisms of the {alpha}2-macroglobulin gene (A2M-I/D and A2M-Ile1000Val) in patients with sporadic AD from southern Italy. The A2M-I and A2M-Val1000 alleles were more frequent in cases than in controls, and this effect was independent from the APOE-{epsilon}4 status as well as from the age at onset of AD. Moreover, subjects carrying the A2M genotype I/I-Val/Val had a threefold increase of risk for AD. These data support a population-based susceptibility for AD linked to A2M polymorphisms.




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M. Zappia, I. Manna, P. Serra, R. Cittadella, V. Andreoli, A. La Russa, F. Annesi, P. Spadafora, N. Romeo, G. Nicoletti, et al.
Increased Risk for Alzheimer Disease With the Interaction of MPO and A2M Polymorphisms
Arch Neurol, March 1, 2004; 61(3): 341 - 344.
[Abstract] [Full Text] [PDF]


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