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Neurology 2002;59:764-766
© 2002 American Academy of Neurology
Brief Communications

P/Q type calcium-channel antibodies in paraneoplastic cerebellar degeneration with lung cancer

F. Graus, MD, B. Lang, PhD, P. Pozo-Rosich, MD, A. Saiz, MD, R. Casamitjana, MD and A. Vincent, FRCPath

From the Services of Neurology (Drs. Graus, Pozo-Rosich, and Saiz) and Hormonal Laboratory (Dr. Casamitjana), Hospital Clínic, Universitat de Barcelona and Institut d’Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; and Neurosciences Group (Drs. Lang and Vincent), Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, United Kingdom.

Address correspondence and reprint requests to Dr. Francesc Graus, Servei de Neurologia, Hospital Clínic. Villarroel 170, Barcelona 08036. Spain; e-mail: graus{at}medicina.ub.es

Raised levels of P/Q type voltage-gated calcium-channel (VGCC) antibodies were found in 16 (41%) of 39 patients with paraneoplastic cerebellar degeneration (PCD) and Hu antibodies were found in nine (23%). Seven of the 16 VGCC antibody-positive patients had Lambert–Eaton myasthenic syndrome (LEMS). Seven of 15 CSF samples had VGCC antibodies, with evidence of intrathecal synthesis in four. VGCC antibodies should be looked for in PCD, even if there are no symptoms of LEMS, and may be related to the cerebellar dysfunction.




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