Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van der Flier, W. M.
Right arrow Articles by van Buchem, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van der Flier, W. M.
Right arrow Articles by van Buchem, M. A.
Related Collections
Right arrow All Imaging
Right arrow MRI
Right arrow Volumetric MRI
Right arrow Neuropsychological assessment
Right arrow All Cognitive Disorders/Dementia
Right arrow Alzheimer's disease
Right arrow Cognitive aging
Right arrow Assessment of cognitive disorders/dementia
Right arrow MCI (mild cognitive impairment)

Neurology 2002;59:874-879
© 2002 American Academy of Neurology

Cognitive decline in AD and mild cognitive impairment is associated with global brain damage

W. M. van der Flier, MA, D.M. J. van den Heuvel, MA, A.W. E. Weverling-Rijnsburger, MD, A. Spilt, MD, E.L.E. M. Bollen, MD PhD, R.G. J. Westendorp, MD PhD, H.A. M. Middelkoop, PhD and M. A. van Buchem, MD PhD

From the Departments of Neurology (Drs. Bollen and Middelkoop, and W.M. van der Flier), Radiology (Drs. Spilt and van Buchem, and D.M.J. van den Heuvel), and Geriatrics/Gerontology (Drs. Weverling-Rijnsburger and Westendorp), Leiden University Medical Center; and Department of Cognitive Psychology (Dr. Middelkoop), Faculty of Social Sciences, Leiden University, the Netherlands.

Address correspondence and reprint requests to W.M. van der Flier, Department of Neurology J3R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands; e-mail: W.M.van_der_flier{at}lumc.nl

Objective: To investigate the relationships between structural damage in the whole brain, the temporal lobes, and the frontal lobes and cognitive decline at old age. The authors hypothesized that widespread brain damage as quantified using magnetization transfer imaging (MTI) is related to global cognitive decline, whereas regional damage to the temporal lobes is related to memory impairment, and regional damage to the frontal lobes is related to executive dysfunctioning.

Methods: Cognitive function of 22 patients with probable AD, 13 patients with mild cognitive impairment (MCI), and 28 elderly controls was assessed using an extensive neuropsychological test battery. Structural damage in the whole brain, the temporal lobes, and the frontal lobes was estimated using volumetric MTI analysis. Associations between MTI measures and neuropsychological tests were investigated using Pearson correlation analysis.

Results: MTI measures of the whole brain, as well as the temporal and the frontal lobes, were strongly associated with global cognitive deterioration and impairment in memory, orientation, language, praxis, gnosis, and executive functioning. However, there were no specific cognitive correlates of regional brain damage to the temporal and frontal lobes.

Conclusions: Using whole brain volumetric magnetization transfer imaging, the authors demonstrated that cognitive decline in patients with mild cognitive impairment and AD is associated with widespread structural brain damage. As there were no specific relationships between regional brain damage and impairment of specific cognitive functions, pathology in AD and mild cognitive impairment is much more generalized than was expected.




This article has been cited by other articles:


Home page
 Arch NeurolHome page
M. G. M. Olde Rikkert, W. M. van der Flier, F. E. deLeeuw, M. Verbeek, R. W. M. M. Jansen, F. Verhey, and P. Scheltens
Multiple Diagnostic Tests Are Needed to Assess Multiple Causes of Dementia
Arch Neurol, January 1, 2006; 63(1): 144 - 146.
[Full Text] [PDF]

Home page
 AM J ALZHEIMERS DIS OTHER DEMENHome page
M. G. M. O. Rikkert, J.-P. Teunisse, and M. Vernooij-Dassen
One hundred years of Alzheimer's disease and the neglected second lesson of Alois Alzheimer on multicausality in dementia
American Journal of Alzheimer's Disease and Other Dementias, September 1, 2005; 20(5): 269 - 272.
[PDF]

Home page
 RadiologyHome page
A. Spilt, A. W. E. Weverling-Rijnsburger, H. A. M. Middelkoop, W. M. van Der Flier, J. Gussekloo, A. J. M. de Craen, E. L. E. M. Bollen, G. J. Blauw, M. A. van Buchem, and R. G. J. Westendorp
Late-Onset Dementia: Structural Brain Damage and Total Cerebral Blood Flow
Radiology, September 1, 2005; 236(3): 990 - 995.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. B. Ragin, P. Storey, B. A. Cohen, R. R. Edelman, and L. G. Epstein
Disease burden in HIV-associated cognitive impairment: A study of whole-brain imaging measures
Neurology, December 28, 2004; 63(12): 2293 - 2297.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by AAN Enterprises, Inc.