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Neurology 2002;59:917-919
© 2002 American Academy of Neurology
Brief Communications

Assessment of the neurogenic flare reaction in small-fiber neuropathies

A. Bickel, MD, H. H. Krämer, MD, M. J. Hilz, MD PhD, F. Birklein, MD, B. Neundörfer, MD and M. Schmelz, MD

From the Department of Neurology (Drs. Bickel, Birklein, Hilz, and Neundörfer) and Institute of Physiology I (Drs. Krämer and Schmelz), University Erlangen–Nuremberg, Erlangen, Germany.

Address correspondence and reprint requests to Dr. med. Andreas Bickel, Neurologische Klinik mit Poliklinik, Schwabachanlage 6, D-91054 Erlangen, Germany; e-mail: andreas.bickel{at}neuro.med.uni-erlangen.de

To improve sensitivity of the analysis of axon reflex flare reaction, the authors used a laser Doppler scanner and analyzed flare intensity and size induced by histamine iontophoresis simultaneously at the foot and thigh in patients with small-fiber neuropathy (n = 10) and controls (n = 9). Flare size, but not laser Doppler flux, clearly distinguished patients from controls at both locations (p < 0.01) and may be useful for evaluation of small-fiber neuropathies.




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