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Neurology 2002;59:938-940
© 2002 American Academy of Neurology
Brief Communications

Longitudinal evaluation of leukoaraiosis with whole brain ADC histograms

M. Mascalchi, MD PhD, M. Moretti, MD, R. Della Nave, MD, F. Lolli, MD PhD, C. Tessa, MD, G. Carlucci, MD, L. Bartolini, G. Pracucci, MD, L. Pantoni, MD PhD, M. Filippi, MD and D. Inzitari, MD

From the Radiodiagnostic Section, Department of Clinical Physiopathology (Drs. Mascalchi, Moretti, Della Nave, and Tessa), and Department of Neurological Sciences (Drs. Lolli, Carlucci, Pracucci, Pantoni, and Inzitari, and L. Bartolini), University of Florence; and Neuroimaging Research Unit (Dr. Filippi), Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.

Address correspondence and reprint requests to Dr. Mario Mascalchi, Sezione di Radiodiagnostica, Dipartimento di Fisiopatologia Clinica, Università di Firenze, Viale Morgagni 85, Firenze, Italy; e-mail: m.mascalchi{at}dfc.unifi.it

FLAIR and diffusion-weighted MRI were obtained twice (mean interval 20 ± 4 months) in 10 patients with leukoaraiosis. At follow-up, visual extension of leukoaraiosis was unchanged, whereas the median of whole brain apparent diffusion coefficient (WB-ADC) histogram was increased (p= 0.008) and brain volume index (BVI) was decreased (p = 0.006). WB-ADC histogram and BVI are sensitive to leukoaraiosis and might be considered for monitoring progression of the disease.




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