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Neurology 2002;59:950-953
© 2002 American Academy of Neurology
Brief Communications

A case-control study of HIV-1–related dementia and co-infection with HHV-8

S. Polk, ScM, A. Muñoz, PhD, N. C. Sacktor, MD, F. J. Jenkins, PhD, B. Cohen, MD, E. N. Miller, PhD and L. P. Jacobson, ScD

From the Department of Epidemiology (S. Polk, and Drs. Muñoz and Jacobson), Johns Hopkins University Bloomberg School of Public Health, and Department of Neurology (Dr. Sacktor), Johns Hopkins University School of Medicine, Baltimore, MD; Departments of Pathology and Infectious Diseases and Microbiology (Dr. Jenkins), University of Pittsburgh, PA; Department of Neurology (Dr. Cohen), Northwestern University Medical School, Chicago, IL; and Neuropsychiatric Institute (Dr. Miller), University of California, Los Angeles.

Address correspondence and reprint requests to Dr. Lisa P. Jacobson, Department of Epidemiology, Room E7006, Johns Hopkins University School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205; e-mail: ljacobso{at}jhsph.edu

This nested case-control study assessed the putative protective effect of human herpesvirus-8 (HHV-8) against HIV-1–related dementia (dementia). The HHV-8 seropositivity of 210 male age- and HIV disease stage–matched cases and controls was compared. The overall HHV-8 seropositivity of 66% was similar among demented HIV-infected cases and nondemented HIV-infected controls.






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