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Vagus nerve stimulation therapy, epilepsy, and device parameters

Scientific basis and recommendations for use

From the USC Department of Neurology, Keck School of Medicine, Los Angeles, California (Dr. Heck); Emory University School of Medicine, Atlanta, Georgia (Dr. Helmers); and UCLA Department of Neurology, Los Angeles, California (Dr. DeGiorgio).

Address correspondence and reprint requests to Dr. Christopher M. DeGiorgio, UCLA Department of Neurology, Reed Neurological Research Center, 710 Westwood Plaza, Los Angeles, CA 90024. e-mail: cmd{at}mednet.ucla.edu

Article abstract Our understanding of a precise dose-response relationship for vagus nerve stimulation (VNS) therapy in the treatment of seizures is still evolving. Because several parameters are involved in VNS therapy, the individual contribution of each is not well understood. This review discusses the efficacy of stimulation parameters used in the VNS clinical trials. The background, influence on safety and efficacy, and role in helping to achieve seizure control are discussed for each VNS device parameter: output current, pulse duration, frequency, and duty cycle. Finally, we provide an algorithm for the adjustment of VNS device settings (see Appendices).

This article has been cited by other articles:

				C. DeGiorgio, C. Heck, S. Bunch, J. Britton, P. Green, M. Lancman, J. Murphy, P. Olejniczak, J. Shih, S. Arrambide, et al. Vagus nerve stimulation for epilepsy: Randomized comparison of three stimulation paradigms Neurology, July 26, 2005; 65(2): 317 - 319. [Abstract] [Full Text] [PDF]

				A. R. C. Kelso and H. R. Cock Advances in epilepsy Br. Med. Bull., April 21, 2005; 72(1): 135 - 148. [Abstract] [Full Text] [PDF]