HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sotgiu, S. Articles by Dolei, A. Search for Related Content PubMed PubMed Citation Articles by Sotgiu, S. Articles by Dolei, A. Related Collections All Infections Viral infections Multiple sclerosis

Multiple sclerosis–associated retrovirus and MS prognosis

An observational study

From the Institute of Clinical Neurology (Drs. Sotgiu, Pugliatti, Rosati, and Arru) and Section of Microbiology, Department of Biomedical Sciences (Drs. Serra, Mameli, and Dolei), University of Sassari, Italy.

Address correspondence and reprint requests to Dr. Stefano Sotgiu, Istituto di Clinica Neurologica, Università di Sassari, Viale San Pietro, 10 I-07100-Sassari, Italy; e-mail: stesot{at}hotmail.com

MS-associated retrovirus (MSRV) in the CSF may have gliotoxic properties and could be associated with a more disabling MS. The authors tested this hypothesis in 15 untreated patients with MS: 6 MSRV- and 9 MSRV+ at the time of CSF withdrawal. After a 3-year mean follow-up, MSRV- patients showed a stable MS course, whereas MSRV+ patients had a progressive course (p = 0.01).

This article has been cited by other articles:

				M Saresella, A Rolland, I Marventano, R Cavarretta, D Caputo, P Marche, H Perron, and M Clerici Multiple sclerosis-associated retroviral agent (MSRV)-stimulated cytokine production in patients with relapsing-remitting multiple sclerosis Multiple Sclerosis, April 1, 2009; 15(4): 443 - 447. [Abstract] [PDF]

				R Alvarez-Lafuente, M Garcia-Montojo, V De Las Heras, M. Dominguez-Mozo, M Bartolome, M. Benito-Martin, and R Arroyo Herpesviruses and human endogenous retroviral sequences in the cerebrospinal fluid of multiple sclerosis patients Multiple Sclerosis, June 1, 2008; 14(5): 595 - 601. [Abstract] [PDF]

				G. Mameli, V. Astone, G. Arru, S. Marconi, L. Lovato, C. Serra, S. Sotgiu, B. Bonetti, and A. Dolei Brains and peripheral blood mononuclear cells of multiple sclerosis (MS) patients hyperexpress MS-associated retrovirus/HERV-W endogenous retrovirus, but not Human herpesvirus 6 J. Gen. Virol., January 1, 2007; 88(1): 264 - 274. [Abstract] [Full Text] [PDF]

				S Sotgiu, G Arru, G Mameli, C Serra, M Pugliatti, G Rosati, and A Dolei Multiple sclerosis-associated retrovirus in early multiple sclerosis: a six-year follow-up of a Sardinian cohort Multiple Sclerosis, November 1, 2006; 12(6): 698 - 703. [Abstract] [PDF]

				A. Rolland, E. Jouvin-Marche, C. Viret, M. Faure, H. Perron, and P. N. Marche The Envelope Protein of a Human Endogenous Retrovirus-W Family Activates Innate Immunity through CD14/TLR4 and Promotes Th1-Like Responses. J. Immunol., June 15, 2006; 176(12): 7636 - 7644. [Abstract] [Full Text] [PDF]

				S Sotgiu, G Arru, M Soderstrom, G Mameli, C Serra, and A Dolei Multiple sclerosis-associated retrovirus and optic neuritis Multiple Sclerosis, June 1, 2006; 12(3): 357 - 359. [Abstract] [PDF]

				A Petzold, H Perron, K T. Fernando, and G. T Plant No evidence for MSRV viraemia and glial cell death in acute optic neuritis Multiple Sclerosis, August 1, 2005; 11(4): 495 - 496. [PDF]