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Neurology 2002;59:1077-1079
© 2002 American Academy of Neurology
Brief Communications

The overlap of amyotrophic lateral sclerosis and frontotemporal dementia

Catherine Lomen-Hoerth, MD PhD, Thomas Anderson, MD and Bruce Miller, MD

From the University of California, San Francisco (Drs. Lomen-Hoerth and Miller), and the University of California, Los Angeles (Dr. Anderson).

Address correspondence and reprint requests to Dr. Catherine Lomen-Hoerth, University of California, San Francisco, 505 Parnassus Ave. M798, San Francisco, CA 94143.

Patients with frontotemporal dementia (FTD) with no known diagnosis of ALS or family history of ALS were clinically and electrophysiologically assessed for the presence of ALS. Of 36 patients studied, five met criteria for a definite diagnosis of ALS and two had EMG findings suggestive of denervation in one limb. An additional five patients had prominent fasciculations and six other patients had trouble swallowing but all had normal results on EMG studies. One of the patients with fasciculations and a normal EMG study progressed to definite ALS over the course of 1 year.




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