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From the Department of Neurology (Drs. Chiang, Pan, and Hsieh, and Y.-H. Lin), National Taiwan University Hospital, Taipei; and Department of Anatomy and Cell Biology (T.-J. Tseng, W.-M. Lin, and Dr. Hsieh), National Taiwan University College of Medicine, Taipei.
Address correspondence and reprint requests to Dr. Sung-Tsang Hsieh, Department of Anatomy and Cell Biology, Neurology, National Taiwan University College of Medicine, 1 Jen-Ai Rd, Sec. 1, Taipei 10018, Taiwan; e-mail: sthsieh{at}ntumc.org
The authors evaluated epidermal nerve density (END) and thermal thresholds in 18 patients with chronic inflammatory demyelinating polyneuropathy (CIDP). END of patients with CIDP were lower than those of controls (4.5 ± 2.9 vs 10.5 ± 3.9 fibers/mm, p < 0.001). Reduced END were associated with autonomic symptoms. Thermal thresholds of patients with CIDP were elevated (88.2% for warm stimuli and 70.6% for cold stimuli). Patients with CIDP have small-fiber sensory and autonomic neuropathies.
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