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Neurology 2002;59:1099-1101
© 2002 American Academy of Neurology
Brief Communications

Migraine with aura is not linked to the FHM gene CACNA1A or the chromosomal region, 19p13

S.E. Noble-Topham, MSc, D.A. Dyment, MSc, M.Z. Cader, MBChB MRCP, R. Ganapathy, MSc, J.D. Brown, MD FRCP(C), G.P.A. Rice, MD FRCP(C) and G.C. Ebers, MD FRCP(C)

From the Lawson Health Research Institute (S.E. Noble-Topham), Department of Clinical Neurological Sciences (Drs. Brown, Rice, and Ebers), London Health Sciences Centre, and the Department of Microbiology (R. Ganapathy), University of Western Ontario, London, Canada; and Department of Clinical Neurology (Dr. Ebers), Radcliffe Infirmary and Wellcome Trust Centre for Human Genetics (D.A. Dyment, M.Z. Cader, and Dr. Ebers), University of Oxford, Oxford, UK.

Address correspondence and reprint requests to Dr. George C. Ebers, Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford, UK, OX2 6HE; e-mail: george.ebers{at}clneuro.ox.ac.uk

Two microsatellite markers, tightly linked to CACNA1A, were genotyped in migraine with aura (MA) families to determine if this gene, which underlies the 19p13 linked forms of familial hemiplegic migraine, is also linked to MA. Two-point parametric lod and nonparametric linkage scores did not support linkage. Transmission disequilibrium testing provided no evidence for linkage of MA to CACNA1A. In a large dataset of 64 Canadian MA families, the authors did not find evidence to support an MA susceptibility gene in the region of 19p13.




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Z. M. Cader, S. Noble-Topham, D. A. Dyment, S. S. Cherny, J. D. Brown, G. P.A. Rice, and G. C. Ebers
Significant linkage to migraine with aura on chromosome 11q24
Hum. Mol. Genet., October 1, 2003; 12(19): 2511 - 2517.
[Abstract] [Full Text] [PDF]


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