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Neurology 2002;59:1102-1104
© 2002 American Academy of Neurology
Brief Communications

Neuroleptic malignant syndrome with prolonged catatonia in a dopa-responsive dystonia patient

M. Ihara, MD, N. Kohara, MD PhD, F. Urano, MSc, H. Ichinose, PhD, S. Takao, MD, T. Nishida, MD, H. Saiki, MD, Y. Kawamoto, MD PhD, A. Ikeda, MD PhD, S. Takagi, MD PhD and H. Shibasaki, MD PhD

From the Departments of Neurology (Drs. Ihara, Kohara, Takao, Saiki, Kawamoto, Ikeda, and Shibasaki) and Neuropsychiatry (Drs. Nishida and Takagi), Kyoto University Graduate School of Medicine; and Institute for Comprehensive Medical Science (F. Urano and Dr. Ichinose), Fujita Health University, Aichi, Japan.

Address correspondence and reprint requests to Dr. M. Ihara, Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan; e-mail: ihara{at}kuhp.kyoto-u.ac.jp

The authors describe a patient with dopa-responsive dystonia who developed neuroleptic malignant syndrome with prolonged catatonia following treatment with neuroleptic agents. Use of these agents probably expanded the patient’s neuronal dysfunction beyond the nigrostriatal system to involve multiple dopaminergic systems. Electroconvulsive treatment alleviated the prolonged catatonia.






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