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Neurology 2002;59:1249-1251
© 2002 American Academy of Neurology
Brief Communications

High-dose thiopental in the treatment of refractory status epilepticus in intensive care unit

I. Parviainen, MD PhD, A. Uusaro, MD PhD, R. Kälviäinen, MD PhD, E. Kaukanen, MD, E. Mervaala, MD PhD and E. Ruokonen, MD PhD

From the Departments of Anesthesiology and Intensive Care (Drs. Parviainen, Uusaro, and Ruokonen), Neurology (Dr. Kälviäinen), Clinical Radiology (Dr. Kaukanen), and Clinical Neurophysiology (Dr. Mervaala), Kuopio University Hospital, Kuopio, Finland.

Address correspondence and reprint requests to Ilkka Parviainen, Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Puijonlaaksontie 2, SF-70211 Kuopio, Finland; e-mail: ilkka.parviainen{at}kuh.fi

The authors studied prospectively the effects of thiopental anesthesia on seizure control, hemodynamics, and the course of intensive care in 10 patients with refractory status epilepticus. Clinical and electrophysiological seizures were terminated in every patient. Hemodynamically, thiopental was well tolerated, but slow recovery from anesthesia prolonged the need for intensive care.




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