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Enhancement of use-dependent plasticity by D-amphetamine

From the Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD.

Address correspondence and reprint requests to Dr. Leonardo G. Cohen, Bldg. 10, Rm. 5N 226, NIH, 10 Center Dr., MSC 1428, Bethesda, MD 20892-1428; e-mail: cohenl{at}ninds.nih.gov

In healthy individuals, motor training can elicit use-dependent plasticity. Here the authors studied six subjects in whom training alone failed to elicit this effect. Administration of a single dose of 10 mg of D-amphetamine preceding training led to use-dependent plasticity in a subgroup of these subjects. Using pharmacologic interventions to enhance the effects of motor training might help rehabilitative efforts in patients in whom training alone fails.

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