Neurology 2002;59:1313-1319
© 2002 American Academy of Neurology
Amount and type of alcohol and risk of dementia
The Copenhagen City Heart Study
Thomas Truelsen, MD PhD,
Dorte Thudium, MD PhD and
Morten Grønbæk, MD DrMedSci
From the Danish Epidemiology Science Centre at the Institute of Preventive Medicine (Dr. Truelsen), Kommunehospitalet, and Centre for Alcohol Research (Drs. Thudium and Grønbæk), National Institute of Public Health, Copenhagen, Denmark.
Address correspondence and reprint requests to Dr. Thomas Truelsen, Institute of Preventive Medicine, Kommunehospitalet, Øster Farimagsgade 5, DK-1399 Copenhagen K, Denmark; e-mail: truelsen{at}post3.tele.dk
Objective: To assess whether amount or type of alcohol is associated with risk of dementia.
Methods and subjects: Case-control nested in a cohort study among participants in the third Copenhagen City Heart Study (1991 to 1994), aged 65 years or more, who where screened using the Mini-Mental State Examination and subsequently examined for dementia. There were 83 subjects diagnosed with dementia and the remaining 1,626 nondemented subjects were included as controls. The two groups were compared with regard to alcohol intake and type of alcohol assessed 15 years before.
Results: Average weekly total alcohol intake had no significant effect on risk of dementia. Monthly and weekly intake of wine was significantly associated with a lower risk of dementia. For beer and spirits, only a monthly intake of beer was significantly associated with an increased risk of dementia. The effect of alcohol on risk of dementia did not differ between men and women.
Conclusions: Monthly and weekly intake of wine is associated with a lower risk of dementia. The results do not indicate that people should start drinking or increase wine consumption to avoid dementia, but instead suggest that certain substances in wine may reduce the occurrence of dementia.
This article has been cited by other articles:
|
|
|
|
 
R. K. Minor, J. S. Allard, C. M. Younts, T. M. Ward, and R. de Cabo
Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction
J Gerontol A Biol Sci Med Sci,
July 1, 2010;
65A(7):
695 - 703.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Vingtdeux, L. Giliberto, H. Zhao, P. Chandakkar, Q. Wu, J. E. Simon, E. M. Janle, J. Lobo, M. G. Ferruzzi, P. Davies, et al.
AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-{beta} Peptide Metabolism
J. Biol. Chem.,
March 19, 2010;
285(12):
9100 - 9113.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Ono, M. M. Condron, L. Ho, J. Wang, W. Zhao, G. M. Pasinetti, and D. B. Teplow
Effects of Grape Seed-derived Polyphenols on Amyloid {beta}-Protein Self-assembly and Cytotoxicity
J. Biol. Chem.,
November 21, 2008;
283(47):
32176 - 32187.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Peters, J. Peters, J. Warner, N. Beckett, and C. Bulpitt
Alcohol, dementia and cognitive decline in the elderly: a systematic review
Age Ageing,
September 1, 2008;
37(5):
505 - 512.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Mehlig, I. Skoog, X. Guo, M. Schutze, D. Gustafson, M. Waern, S. Ostling, C. Bjorkelund, and L. Lissner
Alcoholic Beverages and Incidence of Dementia: 34-Year Follow-up of the Prospective Population Study of Women in Goteborg
Am. J. Epidemiol.,
March 15, 2008;
167(6):
684 - 691.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. M. Brust
A 74-Year-Old Man With Memory Loss and Neuropathy Who Enjoys Alcoholic Beverages
JAMA,
March 5, 2008;
299(9):
1046 - 1054.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Stroud, V. Steiner, and C. Iwuagwu
Predictors of depression among older adults with dementia
Dementia,
February 1, 2008;
7(1):
127 - 138.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. L. Kalev-Zylinska and M. J. During
Paradoxical Facilitatory Effect of Low-Dose Alcohol Consumption on Memory Mediated by NMDA Receptors
J. Neurosci.,
September 26, 2007;
27(39):
10456 - 10467.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Solfrizzi, A. D'Introno, A. M. Colacicco, C. Capurso, A. Del Parigi, G. Baldassarre, P. Scapicchio, E. Scafato, M. Amodio, A. Capurso, et al.
Alcohol consumption, mild cognitive impairment, and progression to dementia
Neurology,
May 22, 2007;
68(21):
1790 - 1799.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Marambaud, H. Zhao, and P. Davies
Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-{beta} Peptides
J. Biol. Chem.,
November 11, 2005;
280(45):
37377 - 37382.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ganguli, J. V. Bilt, J. A. Saxton, C. Shen, and H. H. Dodge
Alcohol consumption and cognitive function in late life: A longitudinal community study
Neurology,
October 25, 2005;
65(8):
1210 - 1217.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Espeland, L. Gu, K. H. Masaki, R. D. Langer, L. H. Coker, M. L. Stefanick, J. Ockene, S. R. Rapp, and for the Women's Health Initiative Memory Study
Association between Reported Alcohol Intake and Cognition: Results from the Women's Health Initiative Memory Study
Am. J. Epidemiol.,
February 1, 2005;
161(3):
228 - 238.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Samuels
Update in Neurology
Ann Intern Med,
January 4, 2005;
142(1):
28 - 36.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. M. Pinder and M. Sandler
Alcohol, wine and mental health: focus on dementia and stroke
J Psychopharmacol,
December 1, 2004;
18(4):
449 - 456.
[Abstract]
[PDF]
|
|
|
|
|
|
|
T. den Heijer, S. E Vermeer, E. J van Dijk, N. D Prins, P. J Koudstaal, C. M van Duijn, A. Hofman, and M. M. Breteler
Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia
Am. J. Clinical Nutrition,
October 1, 2004;
80(4):
992 - 997.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Anttila, E.-L. Helkala, M. Viitanen, I. Kareholt, L. Fratiglioni, B. Winblad, H. Soininen, J. Tuomilehto, A. Nissinen, and M. Kivipelto
Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study
BMJ,
September 4, 2004;
329(7465):
539.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Does Moderate Wine Drinking Reduce the Risk for Dementia?
Journal Watch Neurology,
January 10, 2003;
2003(110):
2 - 2.
[Full Text]
|
|
|
|
|
|
|
A. Culebras
International Newsletter
Neurology,
December 24, 2002;
59(12):
31A - 32.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C.M. Brust
Wine, flavonoids, and the "water of life"
Neurology,
November 12, 2002;
59(9):
1300 - 1301.
[Full Text]
[PDF]
|
|
|
|
