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From the Departments of Psychiatry (Drs. Berney and Guex), Neurology (Drs. Vingerhoets, Perrin, and Ghika), and Neurosurgery (Dr. Villemure), CHUV, Lausanne, Switzerland; the Department of Neurology (Drs. Vingerhoets and Burkhard), HUG, Geneva, Switzerland; and the Neurobiological Psychiatry Unit (Drs. Berney and Benkelfat), McGill University, Montreal, Canada.
Address correspondence and reprint requests to Dr. A. Berney, Research and Training Building, McGill University, 1033 Pine Av. West, H3A1A1, Montreal, Canada; e-mail: aberne1{at}po-box.mcgill.ca
A series of 24 consecutive PD patients were prospectively studied prior to and within 6 months postoperatively for mood, motor, and cognitive status to investigate the effects on mood of subthalamic deep brain stimulation (DBS) in PD. In six patients (25%), mood state worsened significantly, and three were transiently suicidal despite clear motor improvement. Caregivers and patients should be educated about the potential impact of this neurosurgical procedure on mood.
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