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Volume 59, Number 9, November 12, 2002
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Neurology 2002;59:1442-1444
© 2002 American Academy of Neurology


Brief Communications

Intratympanic gentamicin injections for Meniere disease Vestibular hair cell impairment and regeneration

C. de Waele, MD, PhD, R. Meguenni, MD, G. Freyss, MD, F. Zamith, N. Bellalimat, P.P. Vidal, MD, PhD and P. Tran Ba Huy, MD

From Service ORL, Hôpital Lariboisière (Drs. Freyss and Tran Ba Huy and F. Zamith and N. Bellalimat), and Laboratoire de Neurobiologie des Réseaux Sensori-moteurs (Drs. de Waele, Meguenni, and Vidal), Paris, France.

Address correspondence and reprint requests to Dr. Catherine de Waele, Laboratoire de Neurobiologie des Réseaux Sensori-moteurs, Faculté de Médecine, 45 rue des Saints Pères, 75270 Paris Cedex 06, France; e-mail: cdw{at}ccr.Jussieu.fr

The authors treated 22 patients with intratympanic gentamicin. Vestibular function was measured using caloric and head impulse tests and vestibular evoked myogenic potentials induced by high amplitude sounds and short duration galvanic currents. Roughly one-third of the patients, after initially losing their caloric responses and displaying refixation saccades to head impulse tests, recovered within 2 years of the lesion. Vertigo did not recur in patients in whom the galvanic response was abolished.




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