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Neurology 2002;59:1450-1453
© 2002 American Academy of Neurology
Brief Communications

Sensitization of trigeminal nociception specific for migraine but not pain of sinusitis

Z. Katsarava, MD, G. Lehnerdt, MD, B. Duda, J. Ellrich, MD PhD, H.C. Diener, MD PhD and H. Kaube, MD

From the Departments of Neurology (Drs. Katsarava and Diener and B. Duda) and Oto-Rhino-Laryngology (Dr. Lehnerdt), University of Essen, Germany; Department of Experimental and Clinical Pharmacology and Toxicology (Dr. Ellrich), University of Erlangen–Nuremberg, Germany; and Institute of Neurology (Dr. Kaube), The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

Address correspondence and reprint requests to Dr. Zaza Katsarava, Department of Neurology, University of Essen, Hufelandstr. 55, 45122 Essen, Germany; e-mail: zaza.katsarava{at}uni-essen.de

Trigeminal pain processing was studied in 14 patients with unilateral migraine attacks and 14 age- and sex-matched patients with comparable unilateral headache from frontal sinusitis. Using a nociception-specific blink reflex method (nBR), a facilitation of nBR responses predominantly on the headache side was observed in migraine, but not in sinusitis. The facilitation of trigeminal nociception may be specific for migraine rather than a consequence of peripheral pain such as frontal sinusitis.




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