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Neurology 2002;59:1453-1456
© 2002 American Academy of Neurology
Brief Communications

CNS demyelination associated with copper deficiency and hyperzincemia

C.I. Prodan, MD, N.R. Holland, MBBS, P.J. Wisdom, MD, S.A. Burstein, MD and S.S. Bottomley, MD

From the Departments of Neurology (Drs. Prodan, Wisdom, and Holland) and Medicine (Drs. Burstein and Bottomley), University of Oklahoma Health Sciences Center, Oklahoma City, OK.

Address correspondence and reprint requests to Dr. Calin I. Prodan, 711 S.L. Young Blvd, PPOB, Suite 215, Oklahoma City, OK 73104; e-mail: calin-prodan{at}ouhsc.edu

CNS demyelination is not a previously reported feature of acquired copper deficiency. The authors report two patients with idiopathic hypocupremia and hyperzincemia, hematologic changes of copper deficiency, and extensive CNS demyelination. Hematologic recovery followed copper supplementation, both initially and after relapse off copper therapy, while serum zinc levels remained high and the neurologic abnormalities only stabilized.




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Correspondence:

Read all Correspondence

Is there an ischemic component due to anemia ?
Dirk Ulbricht
Neurology Online, 25 Nov 2002 [Full text]
Reply to Ulbricht
Calin I. Prodan, et al.
Neurology Online, 25 Nov 2002 [Full text]

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