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From the Department of Neurology (Dr. Lou, A. Reeves, and T. Benice) and Clinical Research Center (Dr. Sexton), Oregon Health & Science University, Portland.
Address correspondence and reprint requests to Dr. Jau-Shin Lou, Department of Neurology, 3181 SW Sam Jackson Park Rd., Mail Code CR120, Portland, OR 97201; e-mail: Louja{at}ohsu.edu
Twenty-five ALS subjects filled out five questionnaires: the ALS Functional Rating Scale, Multidimensional Fatigue Inventory, multidimensional McGill Quality of Life, Center of Epidemiologic StudyDepression Scale, and the Epworth Sleepiness Scale. Fatigue, depression, and excessive somnolence are more pronounced in ALS subjects than in normal controls. Both fatigue and depression are associated with poorer quality of life in subjects with ALS, and should be treated aggressively.
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