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Neurology 2003;60:142-145
© 2003 American Academy of Neurology
Brief Communications

Reduced myo-inositol and total choline measured with cerebral MRS in acute thyrotoxic Graves’ disease

T.V. Elberling, MD, E.R. Danielsen, PhD, Å.K. Rasmussen, Dr MSc, U. Feldt-Rasmussen, Dr MSc, G. Waldemar, Dr MSc and C. Thomsen, Dr MSc

From the Memory Disorders Research Unit (Drs. Elberling and Waldemar), Neuroscience Center, and Departments of Radiology (Drs. Danielsen and Thomsen) and Medical Endocrinology (Drs. Rasmussen and Feldt-Rasmussen), Copenhagen University Hospital, Rigshospitalet, Denmark.

Address correspondence and reprint requests to Professor Gunhild Waldemar, Memory Disorders Research Unit, The Neuroscience Center, Rigshospitalet, Copenhagen University Hospital, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark; e-mail: gunwal{at}rh.dk

Neuropsychiatric symptoms in the acute thyrotoxic phase of Graves’ disease suggest involvement of brain processes. Short-echo-time proton MRS was used to measure the cerebral metabolite profile in newly diagnosed and untreated Graves’ disease. Sixteen patients with Graves’ disease and 18 age- and sex-matched healthy volunteers were studied. The patients had significantly reduced total choline and myo-inositol in the acute phase of Graves’ thyrotoxicosis compared with the healthy volunteers.




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