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 Volume 60, Number 10, May 27, 2003
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Neurology 2003;60:1672-1673
© 2003 American Academy of Neurology
Brief Communications

Anti-ganglioside antibodies in idiopathic and hereditary cerebellar degeneration

Holly A. Shill, MD, Armin Alaedini, PhD, Norman Latov, MD and Mark Hallett, MD

From the Human Motor Control Section, Medical Neurology Branch (Drs. Shill and Hallett), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD; and Department of Neurology and Neuroscience (Drs. Alaedini and Latov), Cornell University, New York, NY.

Address correspondence and reprint requests to Dr. Mark Hallett, Human Motor Control Section, NINDS, NIH, Building 10, Room 5N226, 10 Center Drive, MSC 1428, Bethesda, MD 20892-1428; e-mail: hallettm{at}ninds.nih.gov

Cerebellar degeneration has been associated with gluten sensitivity and celiac disease. Patients with celiac disease may have neuropathy and antibodies to gangliosides. The authors investigated the presence of antiganglioside antibodies in 22 patients with hereditary and nonhereditary ataxia and found 64% reactive in a novel agglutination test.




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