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Prevalence of antigliadin antibodies in ataxia patients

From the Departments of Neurology (Drs. Abele and Klockgether) and Pediatrics (S. Schwartz), University of Bonn, Germany; and Department of Neurology (Dr. Schöls), St. Josef Hospital, Bochum, Germany.

Address correspondence and reprint requests to Dr. T. Klockgether, MD, Department of Neurology, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany; e-mail: klockgether{at}uni-bonn.de

We determined antigliadin antibodies in 95 ataxia patients and 73 controls. Antibodies were positive in 8% of the controls, 19% of patients with sporadic ataxia, 8% of patients with recessive ataxia, and 15% of patients with dominant ataxia. Statistical comparison using ² statistics did not reveal significant differences between the groups. Although we found a trend toward a higher prevalence of antigliadin antibodies in patients with sporadic ataxia and dominant ataxia, our data do not support an association of ataxia with antigliadin antibodies.

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