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Neurology 2003;60:1713-1716
© 2003 American Academy of Neurology
Brief Communications

Differential activation on fMRI of monozygotic twins discordant for AD

A. M. Lipton, MD Ph.D., R. McColl, PhD, C. M. Cullum, PhD, G. Allen, PhD, W. K. Ringe, PhD, F. J. Bonte, MD, E. McDonald, RN and C. D. Rubin, MD

From the Departments of Neurology (Drs. Lipton and Cullum), Psychiatry (Drs. Lipton, Cullum, Allen, and Ringe), Radiology (Drs. McColl and Bonte), and the Mildred Wyatt and Ivor P. Wold Center for Geriatric Care (E. McDonald and Dr. Rubin), University of Texas Southwestern Medical Center at Dallas, Texas.

Address correspondence and reprint requests to Dr. A.M. Lipton, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, 75390-9070; e-mail: anne.lipton{at}utsouthwestern.edu

This is the first report of fMRI in monozygotic twins discordant for AD. FMRI brain activation patterns were examined during visuospatial and verbal working memory tasks. The affected twin had greater parietal involvement bilaterally during both working memory tasks and reduced left dorsolateral prefrontal cortex activity on the visuospatial memory task. Thus, fMRI may identify additional brain regions recruited in patients with AD to perform a given cognitive task.






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