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Neurology 2003;60:1817-1819
© 2003 American Academy of Neurology
Brief Communications

Alteration of the striatal dopaminergic system in human narcolepsy

I. Eisensehr, MD, R. Linke, MD, K. Tatsch, MD, H. von Lindeiner, MD, B. Kharraz, Cand. Med., F. J. Gildehaus, PhD, R. Eberle, MD, T. Pollmacher, MD, A. Schuld, MD and S. Noachtar, MD

From the Departments of Neurology (Drs. Eisensehr, von Lindeiner, and Noachtar, B. Kharraz) and Nuclear Medicine (Drs. Linke, Tatsch, and Gildehaus), University of Munich; Rotkreuzkrankenhaus (Dr. Eberle); and Max Planck Institute of Psychiatry (Drs. Pollmacher and Schuld), Munich, Germany.

Address correspondence and reprint requests to Dr. I. Eisensehr, Department of Neurology, University of Munich, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany; e-mail: eisen{at}nefo.med.uni-muenchen.de

Striatal D2/D3 dopaminergic receptors have been proposed to play a role in cataplexy. The authors studied the striatal presynaptic dopamine transporter and postsynaptic D2-receptors in seven patients with narcolepsy and seven control subjects using [123I](N )-(3-iodopropene-2-yl)-2ß-carbomethoxy-3ß-(4-chlorophenyl)tropane and [123I](S )-2-hydroxy-3-iodo-6-methoxy-([1-ethyl-2-pyrrolidinyl]methyl)benzamide SPECT. D2-Receptor binding was elevated in narcolepsy (p = 0.017) and correlated with the frequency of cataplectic and sleep attacks (R ≥ 0.844, p ≤ 0.017). The human striatal dopaminergic system is altered in vivo in narcolepsy/cataplexy.




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