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From the Epilepsy Surgery Center "C. Munari" (Drs. Mai, Tassi, Cossu, Francione, and Lo Russo), Departments of Neuroradiology (Dr. Citterio) and Pathology (C. Galli), Niguarda Hospital; and Departments of Experimental Neurophysiology and Neuroanatomy (Drs. Garbelli, Spreafico, and A. Ferrario) and Genetics (Dr. Taroni), Istituto Nazionale Neurologico "C. Besta," Milan, Italy.
Address correspondence and reprint requests to Dr. Roberto Spreafico, Neurofisiologia Sperimentale e Neuroanatomia, Istituto Nazionale Neurologico "C. Besta," Via Celoria 11, 20133 Milan, Italy; e-mail: spreafico{at}istituto-besta.it
The authors performed an MRI, stereo-EEG, and pathology study on a woman with subcortical band heterotopia and partial epilepsy. Clinical manifestations of seizures always started when ictal discharges were present in outer and heterotopic cortices. Simultaneous activation of both cortices and presence of differentiated neurons in the white matter and the heterotopia strongly suggest that the cortices were anatomically and functionally interconnected.
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