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From the Departments of Clinical Neurological Sciences (Drs. Mirsattari and Blume) and Radiology (Dr. Lee), University of Western Ontario; and Department of Neurology (Dr. Jones), University of British Columbia, Canada.
Address correspondence and reprint requests to Dr. Warren T. Blume, Epilepsy and Clinical Neurophysiology, Department of Clinical Neurological Sciences, London Health Sciences Centre, 339 Windermere Road, London, Ontario, Canada N6A 5A5; e-mail: warren.blume{at}lhsc.on.ca
Pathogenesis of a rarely occurring transient, isolated focal lesion of the splenium of the corpus callosum in epilepsy patients is uncertain: frequent seizures or antiepileptic drug reduction causing ischemia or demyelination is possible. The several MRI sequences, including diffusion-weighted imaging, in this first case of occipital epilepsy suggest ischemia from rapid carbamazepine reduction, frequent seizures, or a combination of both.
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