Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Trott, C. T.
Right arrow Articles by Stern, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Trott, C. T.
Right arrow Articles by Stern, Y.
Related Collections
Right arrow Parkinson's disease/Parkinsonism
Right arrow All Clinical trials
Right arrow Clinical trials Randomized controlled (CONSORT agreement)
Right arrow All Cognitive Disorders/Dementia
Right arrow Parkinson's disease with dementia

Neurology 2003;60:1938-1943
© 2003 American Academy of Neurology

Cognition following bilateral implants of embryonic dopamine neurons in PD

A double blind study

C. T. Trott, PhD, S. Fahn, MD, P. Greene, MD, S. Dillon, RN, H. Winfield, RN, L. Winfield, RN, R. Kao, D. Eidelberg, MD, C. R. Freed, MD, R. E. Breeze, MD and Y. Stern, PhD

From the Cognitive Neuroscience Division (Drs. Trott and Stern), G.H. Sergievsky Center, and Department of Neurology (Drs. Fahn, Greene, and Stern, and S. Dillon, H. Winfield, L. Winfield, and R. Kao), Columbia University, New York, NY; North Shore University Hospital (Dr. Eidelberg), Manhasset, NY; and Department of Neurosurgery (Drs. Freed and Breeze), University of Colorado Medical Center, Denver.

Address correspondence and reprint requests to Dr. Yaakov Stern, Sergievsky Center, 630 W 168 St., New York, NY 10032; e-mail: ys11{at}columbia.edu

Objectives: To determine if bilateral transplantation of embryonic mesencephalic dopamine cells into the putamen of patients with PD significantly affected their cognitive functioning when compared with patients receiving sham surgery and to examine the effect of age on cognitive performance after implantation.

Methods: Forty patients (19 women, 21 men; age 34 to 75 years) with idiopathic PD of at least 7 years’ duration (mean 14 years) who had disabling motor signs despite optimal drug management were randomly assigned to tissue implants or sham craniotomies in a double-blind design. Neuropsychological tests assessing orientation, attention, language, verbal and visual memory, abstract reasoning, executive function, and visuospatial and construction abilities were administered before and 1 year after surgery. Treatment groups did not differ at baseline in demographic, neuropsychological, motor, depression, or levodopa equivalent measures.

Results: Postsurgical change in cognitive performance was not significantly different for real or sham surgery groups. Performance in both groups remained unchanged at follow-up for most measures.

Conclusions: Embryonic dopamine producing neurons can be implanted safely into the putamen bilaterally without impairing cognition in patients with PD, but within the first year, improved cognition should not be expected.




This article has been cited by other articles:


Home page
 BMJHome page
Minerva
BMJ, July 10, 2003; 327(7406): 112 - 112.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by AAN Enterprises, Inc.