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Neurology 2003;60:1991-1992
© 2003 American Academy of Neurology
Brief Communications

Neurotoxicity following addition of intravenous valproate to lamotrigine therapy

J. G. Burneo, MD, N. Limdi, PharmD, R. I. Kuzniecky, MD, R. C. Knowlton, MD, M. Mendez, MD, N. Lawn, MD, E. Faught, MD, T. E. Welty, PharmD and A. Prasad, MD

From the Epilepsy Division (Drs. Burneo, Limdi, Kuzniecky, Knowlton, Mendez, Faught, and Prasad), Department of Neurology, University of Alabama School of Medicine, and Departments of Neurology (Dr. Lawn) and Pharmacy (Dr. Welty), McWhorter School of Pharmacy, Samford University, Birmingham.

Address correspondence and reprint requests to Dr. A. Prasad, Epilepsy Division, Department of Neurology, University of Alabama School of Medicine, Birmingham, AL 35294; e-mail: prasad1a{at}uab.edu

Reversible neurotoxic symptoms were observed in three adult patients with absence status epilepticus on lamotrigine (LTG) therapy after administration of an IV bolus followed by oral valproic acid (VPA). Neurotoxicity was likely related to elevated serum LTG levels, as improvement correlated with discontinuing or reducing LTG dosage.




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A. O. Rossetti, E. B. Bromfield, N. A. Limdi, E. Faught, and J. Burneo
Efficacy of rapid IV administration of valproic acid for status epilepticus
Neurology, August 9, 2005; 65(3): 500 - 501.
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