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Neurology 2003;60:2003-2005
© 2003 American Academy of Neurology
Brief Communications

Modulation of the onset age in primary dystonia by APOE genotype

S. Matsumoto, MD, M. Nishimura, MD PhD, T. Sakamoto, MD, K. Asanuma, MD, Y. Izumi, MD PhD, H. Shibasaki, MD PhD, N. Kamatani, MD, T. Nakamura, MD and R. Kaji, MD PhD

From the Department of Clinical Neuroscience (Drs. Matsumoto, Nishimura, Sakamoto, Asanuma, Izumi, and Kaji), Tokushima University School of Medicine; Department of Neurology (Dr. Shibasaki), Kyoto University Graduate School of Medicine, Sakyo-ku; Division of Genomic Medicine and Statistical Genetics (Drs. Kamatani and Nakamura), and Department of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University.

Address correspondence and reprint requests to Dr. Shinichi Matsumoto, Department of Clinical Neuroscience, Tokushima University School of Medicine, Kuramoto-cho, Tokushima 770-8503, Japan; e-mail: matsumo{at}medclin.clin.med.tokushima-u.ac.jp

APOE polymorphisms were studied in 200 unrelated patients with primary dystonia as well as 300 age-matched control subjects. Although no difference was found in APOE genotype between the patients with dystonia and the controls, APOE-{epsilon}4 carriers developed the disease on average approximately 10 years earlier than APOE-{epsilon}4 noncarriers (p = 0.0012). This suggests that APOE-{epsilon}4 genotype affects the clinical presentation of primary dystonia.






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