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Neurology 2003;60:2006-2007
© 2003 American Academy of Neurology
Brief Communications

Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients

F. Baskin, PhD, R. N. Rosenberg, MD, X. Fang, MD, L. S. Hynan, PhD, C. B. Moore, MA, M. Weiner, MD and G. L. Vega, PhD

From the Departments of Neurology (Drs. Baskin, Rosenberg, and Fang), Psychiatry and Academic Computing Services (Drs. Weiner and Hynan, and C.B. Moore), Center for Human Nutrition and Clinical Nutrition (Dr. Vega), University of Texas Southwestern Medical Center at Dallas.

Address correspondence and reprint requests to Dr. F. Baskin, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9036; e-mail: Fred.Baskin{at}UTSouthwestern.edu

Platelets, like neurons, contain 120- to 130- and 110-kd amyloid precursor proteins (APPs). Their ratio is reduced in AD, further reductions correlating with reduced Mini-Mental Status Examination scores [r(11) = 0.69, p < 0.05]. As statins alter APP processing, platelet APPs were analyzed in patients with AD given anticholesterol drugs for 6 weeks. APP ratios increased [t(37) = -3.888, p = 0.0004], proportionally with reduced cholesterol [r(36) = -0.45, p = 0.005]. Longer trials may reveal slowed cognitive loss, validating this index.




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R. N. Rosenberg
Translational Research on the Way to Effective Therapy for Alzheimer Disease
Arch Gen Psychiatry, November 1, 2005; 62(11): 1186 - 1192.
[Abstract] [Full Text] [PDF]


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