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Neurology 2003;60:323-325
© 2003 American Academy of Neurology
Brief Communications

Intercaudate nucleus ratio as a linear measure of brain atrophy in multiple sclerosis

C. Caon, MSN RN, M. Zvartau-Hind, MD, W. Ching, BSc CCRP, R.P. Lisak, MD, A.C. Tselis, MD PhD and O.A. Khan, MD

From the Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan.

Address correspondence and reprint requests to Dr. Omar A. Khan, Department of Neurology, Wayne State University School of Medicine, 4201 St. Antoine, 8D-University Health Center, Detroit, MI 48201.

Intercaudate nucleus ratio (ICR) is a linear measure of brain atrophy that does not require software application and is independent of image acquisition techniques. The authors examined the relationship between ICR and disability in 190 patients with MS. The results show that ICR correlates with Expanded Disability Status Scale score (r = 0.67; p = 0.0001) and disease duration (r = 0.32; p < 0.01). Intercaudate ratio appears to be a reliable and reproducible linear measure of brain atrophy and correlates with disability and disease duration in MS.




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