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Neurology 2003;60:326-328
© 2003 American Academy of Neurology
Brief Communications

Posterior leukoencephalopathy following intrathecal chemotherapy with MRA-documented vasospasm

R.D. Henderson, FRACP, T. Rajah, FRACR, A.J. Nicol, PhD and S.J. Read, PhD

From the Departments of Neurology (Drs. Henderson and Read), Neuroradiology (Dr. Rajah), and Hematology (Dr. Nicol), Royal Brisbane Hospital, Herston, Australia.

Address correspondence and reprint requests to Dr. Robert Henderson, Department of Neurology, Royal Brisbane Hospital, Herston Rd., Herston 4029, Australia; e-mail: Robert_Henderson{at}health.qld.gov.au

Posterior leukoencephalopathy syndromes have been reported with hypertension, and immunosuppressive and chemotherapy agents. Cerebral vasospasm on MR angiography (MRA) has been noted in cases due to eclampsia. The authors report a case of Balint syndrome with irreversible posterior leukoencephalopathy on MRI following intrathecal methotrexate and cytarabine. Hypertension was not present. Diffuse, reversible arterial irregularities consistent with vasospasm were present on MRA during the acute illness.




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