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Evidence of cardiac ischemia during seizures in drug refractory epilepsy patients

From the Departments of Neurology (Drs. Tigaran and Dam) and Cardiology, Skejby Sygehus (Dr. Mølgaard), Aarhus University Hospital, Aarhus, Denmark; and the Department of Biostatistics (Dr. McClelland) and Division of Cardiovascular Diseases and Laboratory Medicine and Pathology (Dr. Jaffe), Mayo Clinic, Rochester, MN.

Address correspondence and reprint requests to Dr. Simona Tigaran, Department of Neurology, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C, Denmark; e-mail: mona{at}akhphd.au.dk

The authors investigated whether patients with drug refractory epilepsy have cardiovascular abnormalities that might be related to a high frequency of sudden death. Twenty-three subjects underwent comprehensive cardiovascular evaluations before and during video-EEG monitoring. ST-segment depression occurred in 40% and was associated with a higher maximum heart rate during seizures. These data suggest that cardiac ischemia may occur in these patients.

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