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From the Departments of Medicine & Therapeutics (Drs. Wong, Liu, and Gao) and Diagnostic Radiology & Organ Imaging (Drs. Lam and Chan), The Chinese University of Hong Kong, Shatin.
Address correspondence and reprint requests to Dr. Ka Sing Wong, Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong; e-mail: ks-wong{at}cuhk.edu.hk
The authors measured the presence and extent of asymptomatic microbleeds on gradient-recalled-echo MRI in 21 aspirin users who developed intracerebral hemorrhage and 21 aspirin users without history of intracerebral hemorrhage. Microbleeds were more frequent (19 vs 7, p < 0.001) and more extensive (mean number of microbleeds 13.3 vs 0.4, p < 0.001) in the intracerebral hemorrhage group than in the control group. Asymptomatic microbleeds may be a risk factor for aspirin-associated intracerebral hemorrhage.
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