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Neurology 2003;60:514-517
© 2003 American Academy of Neurology
Brief Communications

Sporadic Creutzfeldt–Jakob disease with MM1-type prion protein and plaques

C. Ishida, MD PhD, A. Kakishima, MD, S. Okino, MD PhD, Y. Furukawa, MD, M. Kano, MD PhD, Y. Oda, MD PhD, I. Nakanishi, MD PhD, T. Makifuchi, MD PhD, T. Kitamoto, MD PhD and M. Yamada, MD PhD

From the Departments of Neurology and Neurobiology of Aging (Drs. Ishida, Kakishima, Okino, Furukawa, and Yamada) and Molecular and Cellular Pathology (Drs. Oda and Nakanishi), Kanazawa University Graduate School of Medical Science; Department of Neurology (Dr. Kano), National Iou Hospital, Ishikawa; Department of Clinical Research (Dr. Makifuchi), National Saigata Hospital, Niigata; and Department of Neurological Science (Dr. Kitamoto), Tohoku University School of Medicine, Sendai, Japan.

Address correspondence and reprint requests to Dr. Chiho Ishida, Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Takara-machi, 13-1, Kanazawa, Ishikawa 920-8640, Japan; e-mail: cishida{at}noto-hospital.jp

The authors report a 75-year-old woman with atypical sporadic Creutzfeldt–Jakob disease (CJD) characterized by MM1-type prion protein (PrP) (methionine homozygosity at codon 129 in the PrP gene and type-1 protease-resistant PrP) and PrP plaques. This patient is the first case of sporadic CJD with plaque-forming MM1-type PrP, suggesting either a shared prion strain with the plaque-forming subset of dural graft–associated CJD or shared host genetic factors that are unrelated to the PrP genotype.




This article has been cited by other articles:


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R. Y.-Y. Lo, W. C. Shyu, and H. Li
Long-duration sCJD with PRNP codon 129 methionine homozygosity and cerebral cortical plaques
Neurology, June 27, 2006; 66(12): 1944 - 1945.
[Abstract] [Full Text] [PDF]

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 J. Neurol. Neurosurg. PsychiatryHome page
C Ishida, S Okino, T Kitamoto, and M Yamada
Involvement of the peripheral nervous system in human prion diseases including dural graft associated Creutzfeldt-Jakob disease
J. Neurol. Neurosurg. Psychiatry, March 1, 2005; 76(3): 325 - 329.
[Abstract] [Full Text] [PDF]

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 NeurologyHome page
G. Puoti, L. Limido, R. Cotrufo, G. Di Fede, F. Tagliavini, C. Ishida, T. Kitamoto, and M. Yamada
Sporadic Creutzfeldt-Jakob disease with MM1-type prion protein and plaques
Neurology, April 13, 2004; 62(7): 1239 - 1239.
[Full Text] [PDF]

Correspondence:

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Sporadic Creutzfeldt–Jakob disease with MM1-type prion protein and plaques
Gianfranco Puoti, et al.
Neurology Online, 4 Sep 2003 [Full text]
Sporadic Creutzfeldt-Jakob disease with MM1-type prion protein and plaques
Chiho Ishida, et al.
Neurology Online, 4 Sep 2003 [Full text]

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