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Neurology 2003;60:548-554
© 2003 American Academy of Neurology
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Death receptors on reactive astrocytes

A key role in the fine tuning of brain inflammation?

Pierre-Yves Dietrich, MD, Paul R. Walker, PhD and Philippe Saas, PhD

From Hôpital Universitaire (Drs. Dietrich and Walker), Division d’Oncologie, Laboratoire d’Immunologie des Tumeurs, Switzerland; and Etablissement Français du Sang de Bourgogne Franche Comté (Dr. Saas), Laboratoire d’Immunologie, INSERM E-0119, UPRES EA 2284, Université de Franche Comté, Besançon cedex, France.

Address correspondence and reprint requests to Dr. Pierre-Yves Dietrich, Hôpital Universitaire, Division d’Oncologie, 1211 Genève 14, Switzerland; e-mail: pierre-yves.dietrich{at}hcuge.ch

Immune responses protect the CNS against pathogens. However, the fact that there is little dispensable tissue in the brain makes regulation necessary to avoid disastrous immune-mediated damage. Astrocytes respond vigorously to any brain injury (e.g., tumor, stroke, AD, MS, HIV) and are postulated to play an important role in the fine tuning of brain inflammation. The authors propose that astrocytes use death receptors to modulate pro- and anti-inflammatory effects.




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