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Neurology 2003;60:702-705
© 2003 American Academy of Neurology
Brief Communications

Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin

Guy J. Buckle, MD, Per Höllsberg, MD and David A. Hafler, MD

From the Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA.

Address correspondence and reprint requests to Dr. David A. Hafler, Center for Neurologic Diseases, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115.

The authors compared the functional activation state and cytokine secretion profile of CD8+ T cells in patients with relapsing-remitting and secondary progressive (SP) MS to those in normal controls. In addition, they examined cytokine secretion in relationship to single nucleotide polymorphism (SNP) analysis of cytokine genes. A significant increase in lymphotoxin secretion from anti-CD3-stimulated CD8+ T cells was observed in patients with SPMS as compared to normal controls. The authors found no significant differences in SNP frequency or in secretion of other cytokines.




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