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Facial hemangioma and cerebral corticovascular dysplasia

A syndrome associated with epilepsy

From the Departments of Pediatric Neurology (Drs. Aeby and Van Bogaert) and Neuroradiology (Drs. David and Rodesch), Université Libre de Bruxelles, Hôpital Erasme, Brussels, Belgium; Division of Child Neurology and Psychiatry (Dr. Guerrini), University of Pisa and Rederarch Institute, IRCCS Stella Maris Foundation, Italy; and the Department of Neuroradiology (Dr. Raybaud), Centre Hospitalier Régional et Universitaire de Marseille, France.

Address correspondence and reprint requests to Dr. P. Van Bogaert, Department of Pediatric Neurology, ULB-Hôpital Erasme, 808 route de Lennik, B-1070 Brussels, Belgium; e-mail: pvanboga{at}ulb.ac.be

The authors performed imaging studies in two children with epilepsy and congenital facial hemangioma. The first patient had dysplastic pericallosal arteries and frontal polymicrogyria. In the second patient, dysplastic arteries and dysplastic cortex lined the interhemispheric fissure, the dysplastic cortex bridging across the midline, which resulted in holoprosencephaly. Abnormal cortical development may underlie epilepsy in children with facial hemangioma.

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