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Neurotransmitter specificity of sympathetic denervation in Parkinson’s disease

From the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.

Address correspondence and reprint requests to Dr. David S. Goldstein, Clinical Neurocardiology Section, NINDS, NIH, Building 10 Room 6N252, 10 Center Drive, MSC-1620, Bethesda, MD 20892-1620; e-mail: goldsteind{at}ninds.nih.gov

In PD, orthostatic hypotension reflects sympathetic noradrenergic denervation. The authors assessed sympathetic cholinergic innervation by the quantitative sudomotor axon reflex test (QSART) in 12 patients who had sympathetic neurocirculatory failure, markedly decreased cardiac 6-[¹⁸F] fluorodopamine-derived radioactivity, and subnormal plasma norepinephrine increments during standing. All 12 had normal QSART results. The sympathetic nervous system lesion in PD involves loss of postganglionic catecholaminergic but not cholinergic nerves.

This article has been cited by other articles:

				D. S. Goldstein, B. A. Eldadah, C. Holmes, S. Pechnik, J. Moak, A. Saleem, and Y. Sharabi Neurocirculatory Abnormalities in Parkinson Disease With Orthostatic Hypotension: Independence From Levodopa Treatment Hypertension, December 1, 2005; 46(6): 1333 - 1339. [Abstract] [Full Text] [PDF]

				G. Eisenhofer, I. J. Kopin, and D. S. Goldstein Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine Pharmacol. Rev., September 1, 2004; 56(3): 331 - 349. [Abstract] [Full Text] [PDF]