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Neurology 2003;60:1039-1042
© 2003 American Academy of Neurology
Brief Communications

Cerebral blood flow changes induced by subthalamic stimulation in Parkinson’s disease

Antonio P. Strafella, MD PhD, Alain Dagher, MD and Abbas F. Sadikot, MD PhD

From Montreal Neurological Institute, McGill University, Montréal, Québec, Canada.

Address correspondence and reprint requests to Dr. A. Dagher, Montreal Neurological Institute, McGill University, Montréal, Québec, Canada H3A 2B4; e-mail: alain{at}bic.mni.mcgill.ca; or Dr. A.F. Sadikot, Montreal Neurological Institute, McGill University, Montréal, Québec, Canada H3A 2B4; e-mail: sadikot@bic.mni.mcgill.ca

The authors used PET to show that the abnormal pattern of cerebral blood flow (CBF) activation described in PD is normalized by electrical stimulation of subthalamic nucleus. Improvement in bradykinesia correlated with increase in CBF due to stimulation in the supplementary motor area and anterior cingulate cortex. Compared to unilateral stimulation, bilateral stimulation induced a greater extent of activation in bilateral cortical areas and additional bilateral activation of globus pallidus.




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