Neurology®
The most widely read and highly cited peer-reviewed Neurology journal
Quick Search
Advanced Search
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Strafella, A. P.
Right arrow Articles by Sadikot, A. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Strafella, A. P.
Right arrow Articles by Sadikot, A. F.
Related Collections
Right arrow PET
Right arrow Parkinson's disease/Parkinsonism
Right arrow Surgery/Stimulation

Neurology 2003;60:1039-1042
© 2003 American Academy of Neurology
Brief Communications

Cerebral blood flow changes induced by subthalamic stimulation in Parkinson’s disease

Antonio P. Strafella, MD PhD, Alain Dagher, MD and Abbas F. Sadikot, MD PhD

From Montreal Neurological Institute, McGill University, Montréal, Québec, Canada.

Address correspondence and reprint requests to Dr. A. Dagher, Montreal Neurological Institute, McGill University, Montréal, Québec, Canada H3A 2B4; e-mail: alain{at}bic.mni.mcgill.ca; or Dr. A.F. Sadikot, Montreal Neurological Institute, McGill University, Montréal, Québec, Canada H3A 2B4; e-mail: sadikot@bic.mni.mcgill.ca

The authors used PET to show that the abnormal pattern of cerebral blood flow (CBF) activation described in PD is normalized by electrical stimulation of subthalamic nucleus. Improvement in bradykinesia correlated with increase in CBF due to stimulation in the supplementary motor area and anterior cingulate cortex. Compared to unilateral stimulation, bilateral stimulation induced a greater extent of activation in bilateral cortical areas and additional bilateral activation of globus pallidus.




This article has been cited by other articles:


Home page
 BrainHome page
M. Karimi, N. Golchin, S. D. Tabbal, T. Hershey, T. O. Videen, J. Wu, J. W. M. Usche, F. J. Revilla, J. M. Hartlein, A. R. Wernle, et al.
Subthalamic nucleus stimulation-induced regional blood flow responses correlate with improvement of motor signs in Parkinson disease
Brain, October 1, 2008; 131(10): 2710 - 2719.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. Herzog, P. H. Weiss, A. Assmus, B. Wefer, C. Seif, P. M. Braun, M. O. Pinsker, H. Herzog, J. Volkmann, G. Deuschl, et al.
Improved sensory gating of urinary bladder afferents in Parkinson's disease following subthalamic stimulation
Brain, January 1, 2008; 131(1): 132 - 145.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. Herzog, P. H. Weiss, A. Assmus, B. Wefer, C. Seif, P. M. Braun, H. Herzog, J. Volkmann, G. Deuschl, and G. R. Fink
Subthalamic stimulation modulates cortical control of urinary bladder in Parkinson's disease
Brain, December 1, 2006; 129(12): 3366 - 3375.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
S. T. Grafton, R. S. Turner, M. Desmurget, R. Bakay, M. Delong, J. Vitek, and M. Crutcher
Normalizing motor-related brain activity: Subthalamic nucleus stimulation in Parkinson disease
Neurology, April 25, 2006; 66(8): 1192 - 1199.
[Abstract] [Full Text] [PDF]