Neurology 2003;60:1175-1178
© 2003 American Academy of Neurology
Brief Communications
Cerebral venous thrombosis
Clinical outcome and systematic screening of prothrombotic factors
S. Cakmak, MD,
L. Derex, MD,
M. Berruyer, PhD,
N. Nighoghossian, MD,
F. Philippeau, MD,
P. Adeleine, PhD,
M. Hermier, MD,
J.C. Froment, MD and
P. Trouillas, MD PhD
From the Service d’Urgences Neurovasculaires (Drs. Cakmak, Derex, Nighoghossian, Philippeau, and Trouillas) and Service de Neuroradiologie (Drs. Hermier and Froment), Hôpital Neurologique, Lyon; Laboratoire Central d’Hématologie et de Cytogénétique (Dr. Berruyer), Hôpital Louis Pradel, Bron; and Service de Biostatistique et d’Informatique Médicale (Dr. Adeleine), Lyon, France.
Address correspondence and reprint requests to Dr. Laurent Derex, Service d’Urgences Neurovasculaires, Hôpital Neurologique, 59, boulevard Pinel, 69003 Lyon, France; e-mail: lderex{at}yahoo.com
The authors studied 16 consecutive cases of cerebral venous thrombosis (CVT). Clinical outcome was good or excellent in 14 patients. Comprehensive hypercoagulable screening was done at least 3 months after the onset of CVT, including evaluation of genetic coagulation disorders and plasma levels of homocysteine and factor VIII. This screening was positive in 12 patients (75%). An acquired prothrombotic factor was identified in 9 of these 12 patients. Elevation of factor VIII plasma level was the most common coagulation disorder (8 patients).
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